کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6009114 1185032 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Slowing of M1 activity in Parkinson's disease during rest and movement - An MEG study
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Slowing of M1 activity in Parkinson's disease during rest and movement - An MEG study
چکیده انگلیسی

ObjectiveParkinson's disease is characterized by motor and cognitive problems that are accompanied by slowing of neural activity. This study examined the relationship between neural slowing and disease severity during rest and motor performance.MethodsPrimary motor activity was assessed by means of magnetoencephalography during rest and rhythmic movements. Motor output and event-related cortical power in the alpha and beta frequency bands were determined. UPDRS total and subscores were used to pinpoint correlates of neural slowing (change of power towards lower frequencies) during both resting state and the production of rhythmic movements.ResultsBy design, motor performance was similar for both the patients and the controls. PD patients showed slowing of neural activity which increased with disease severity. Slowing during rest showed the clearest correlation with cognitive UPDRS subscores, whereas slowing during movement correlated best with the motor UPDRS subscore.ConclusionsThese results suggest that slowing is functionally modulated and that different mechanisms are responsible for neural slowing during rest versus movement.SignificanceNeural slowing must be viewed in a broader context than previously thought because it is not solely related to impaired motor performance but also to impaired cognition.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Neurophysiology - Volume 122, Issue 4, April 2011, Pages 789-795
نویسندگان
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