Effect of a serotonin antagonist on delay in grip muscle relaxation for persons with chronic hemiparetic stroke

► Our findings support the supposition that monoaminergic brainstem pathways may be disinhibited following stroke. ► Disinhibited monoaminergic brainstem pathways appear to result in increased delays in muscle relaxation. ► Treatments to reduce delay in muscle relaxation may facilitate hand rehabilitation in persons with stroke.