کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6015322 1579913 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Enhanced EEG connectivity in children with febrile seizures
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Enhanced EEG connectivity in children with febrile seizures
چکیده انگلیسی


- Source coherence estimates connectivity between cerebral regions while removing global influences.
- Patients with febrile seizures show enhanced connectivity under resting and stimulation conditions.
- Enhanced connectivity could underlie seizure susceptibility.
- Enhanced connectivity could interfere with the maturation of cerebral networks.

SummaryBackgroundEpilepsy is currently conceptualized as a disturbance of neuronal networks with altered connectivity that persists into the interictal phase. Febrile seizures are sometimes a precursor in childhood of lifelong epilepsy. We investigated whether studying functional connectivity in children with febrile seizures could help understand the mechanisms underlying their long-term seizure susceptibility.MethodsEEG was recorded during rest and intermittent photic stimulation (IPS) in 12 FS patients, 5 siblings and 15 control children between 6 and 36 months of age. Original EEG data were transformed into source space using a multiple regional source model. Source coherence values were calculated for the interfrontal, interoccipital and occipito-frontal connections for the delta, theta, alpha, beta and gamma frequency bands.ResultsOur results suggest enhanced delta and theta frequency EEG source coherence in patients with FSs compared to siblings and control children, both under resting conditions and during IPS, more consistent for the theta band and the occipito-frontal connections.ConclusionsEnhanced connectivity in patients with FSs could indicate a seizure-prone state and interfere with the maturation of cerebral networks. Further prospective studies are needed to assess whether hyperconnectivity is a risk factor for epileptogenesis and neurodevelopmental disorders.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy Research - Volume 110, February 2015, Pages 32-38
نویسندگان
, , , , , ,