Thalamic stimulation in absence epilepsy

Low frequency stimulation induced AD, which strongly mimic SWD. Moreover, the effects were site-specific. High frequency thalamic stimulation disrupts ongoing SWD probable by interfering with the slow firing pattern of cortico-thalamo-cortical neurons seen during SWD cycle. The absence of stimulation site specificity for high frequency stimulation might be due to the fact that stimulation only started on average 1 s after SWD onset when SWD are already fully expressed in the bidirectional cortico-thalamo-cortical resonance system.