کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6016283 | 1579937 | 2009 | 9 صفحه PDF | دانلود رایگان |
SummaryBackgroundAbsence epilepsy is characterized clinically by the impairment of consciousness and 3Â Hz generalized spike-wave discharges (GSWDs) on EEG. Clinical absence can be observed with ictal GSWDs, but interictal GSWD bursts are usually clinically silent. Simultaneous EEG and blood-oxygen-level-dependent (BOLD) functional MRI (EEG-fMRI) has been successfully used to link the changes in regional neuronal activity to the occurrence of GSWDs.MethodsWe used EEG-fMRI to investigate and compare the BOLD signal changes during interictal and ictal GSWDs in patients with childhood absence epilepsy (CAE).ResultsFifteen drug-naïve children with newly diagnosed CAE were studied using continuous EEG-fMRI. BOLD signal changes associated with interictal (nine sessions with six patients) and ictal (eight sessions with six patients) GSWDs were analyzed at the individual and group levels. GSWDs were associated with widespread and symmetrical deactivation in the cortex and caudate nucleus with a frontal maximum, and predominant activation in the thalamus bilaterally during ictal GSWDs and in the cortex during interictal GSWDs. The BOLD response was characterized by a higher statistical significance and a more widespread extent at the time of the ictal GSWDs as compared to the time of interictal GSWDs.ConclusionsBoth interictal and ictal GSWDs in patients with CAE are associated with BOLD signal changes in the basal ganglia-thalamocortical loop. Ictal GSWDs showing predominant thalamic activation and widespread cortical deactivation might cause a complete suspension of the normal brain's default state and manifest clinically as abrupt loss of consciousness (absence seizures).
Journal: Epilepsy Research - Volume 87, Issues 2â3, December 2009, Pages 160-168