Visual impairment at large eccentricity in participants treated by vigabatrin: Visual, attentional or recognition deficit?

SummaryA relationship between peripheral visual field loss and vigabatrin (VGB) has been reported in several studies but with inconsistent results. We investigated the level of visual processing at which the impairment occurs: attentional or cognitive (recognition) deficit. A simple reaction time task was used as a baseline condition. A spatial attention task measured the benefit and cost for the detection of a target appearing at a cued or at an uncued location. A rapid categorization task assessed object recognition. Performance was tested at eccentricities varying from 30° to 60° on a panoramic screen covering 180°. Participants were patients with epilepsy treated with VGB, patients treated with other drugs and healthy controls. In the VGB group 9 patients exhibited a mild visual field constriction. We observed a general slowing down of response times in participants treated by VGB, especially at 60° eccentricity but their performance remained above chance at large eccentricity in the most complex categorization task. The slowing down of visual processing at large eccentricity for flashed stimuli suggests that VGB treated patients might be impaired at detecting moving objects in the periphery and this may have consequences in behavioural tasks like driving.