کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6019832 1187431 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neuroprotection with erythropoietin in preterm and/or low birth weight infants
ترجمه فارسی عنوان
محافظت از عصب با اریتروپویتین در نوزادان نارس و یا کم وزن هنگام تولد
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی

Neonatal brain injury caused by extreme prematurity remains a great challenge for prevention. Erythropoietin (EPO) has shown neuroprotective effects in a series of neonatal experimental models and recent clinical trials of premature infants. In this meta-analysis of seven clinical trials, EPO was associated with a highly reproducible reduction in the risk of neurodevelopmental disability in preterm infants. However, there was no difference in the risk for morbidity, cerebral palsy, visual deficit, severe hearing deficit, necrotizing enterocolitis, intracranial hemorrhage and patent ductus arteriosus. The use of EPO, to some extent, is associated with reduction in neurodevelopmental disability in preterm infants. More double blind randomized controlled trials are needed to establish the best therapeutic approach for neuroprotection in preterm infants.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Neuroscience - Volume 21, Issue 8, August 2014, Pages 1283-1287
نویسندگان
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