کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
603413 | 880215 | 2011 | 8 صفحه PDF | دانلود رایگان |
The benefits of increasing surface area to volume ratio have long been realized by the pharmaceutical industry for addressing the solubility limited oral bioavailability. In the recent past various excipients that include but not limited to polymers and lipids are used to engineer nanostructures that possess one or more of the following properties, improve oral bioavailability, improve therapeutic efficacy, sustain the release of the encapsulated bioactive, minimize toxicity, have the ability to target the pathological site of interest and also perform dual role of diagnosis and delivery of bioactives simultaneously. In this review, we attempt to discuss the use of poly(lactide-co-glycolide) (PLGA) nanoparticles in addressing the solubility/permeability limited bioavailability problems of various bioactives that include drugs as well as antioxidants.
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► Increase peroral bioavailability while minimizing the toxicity.
► Increase rate of absorption and overcome GI absorption window.
► Potential to minimize drug attrition rates and offer product life cycle extension.
► Co-encapsulation of multiple bioactives with diverse physicochemical properties.
► Nanoparticle can be route independent drug delivery vehicle.
Journal: Current Opinion in Colloid & Interface Science - Volume 16, Issue 3, June 2011, Pages 238–245