کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6041118 1189266 2015 20 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Treatable renal failure found in non-ambulatory Duchenne muscular dystrophy patients
ترجمه فارسی عنوان
نارسایی قابل درمان قابل درمان در بیماران دیستروفی عضلانی دوچنانی غیر آمبولاسیون یافت می شود
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب تکاملی
چکیده انگلیسی
Duchenne muscular dystrophy (DMD) is a progressive muscular disorder in which respiratory and heart failures are the main causes of death. Intensive intervention in respiratory and cardiac function has dramatically improved the prognosis; however, dysfunction in other multiple organs may emerge in the later stages of the disease. We report the case of four non-ambulatory DMD patients who presented with renal failure. Common findings included decreased fluid intake, use of diuretics, and presence of chronic heart failure. The levels of serum cystatin C (CysC), a marker of kidney function unaffected by reduced muscle mass, were elevated in all four patients. In two patients, renal failure improved by increasing fluid intake, and discontinuing or reducing the dose of diuretics. The findings suggest that non-ambulatory DMD patients are at a risk of reduced kidney perfusion, which potentially leads to prerenal failure. Therefore, in DMD patients, dehydration signs and CysC levels should be monitored.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuromuscular Disorders - Volume 25, Issue 10, October 2015, Pages 754-757
نویسندگان
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