کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6041705 1189314 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Muscle biopsies off-set normal cellular signaling in surrounding musculature
ترجمه فارسی عنوان
بیوپسی عضله خارج کردن سیگنالینگ سلول طبیعی در عضلات اطراف
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب تکاملی
چکیده انگلیسی
Studies of muscle physiology and muscular disorders often require muscle biopsies to answer questions about muscle biology. In this context, we have often wondered if muscle biopsies, especially if performed repeatedly, would affect interpretation of muscle morphology and cellular signaling. We hypothesized that muscle morphology and cellular signaling involved in myogenesis/regeneration and protein turnover can be changed by a previous muscle biopsy in close proximity to the area under investigation. Here we report a case where a past biopsy or biopsies affect cellular signaling of the surrounding muscle tissue for at least 3 weeks after the biopsy was performed and magnetic resonance imaging suggests that an effect of a biopsy may persist for at least 5 months. Cellular signaling after a biopsy resembles what is seen in severe limb-girdle muscular dystrophy type 2I with respect to protein synthesis and myogenesis despite normal histologic appearance.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuromuscular Disorders - Volume 23, Issue 12, December 2013, Pages 981-985
نویسندگان
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