کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6041935 | 1189345 | 2012 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Membrane excitability and excitation-contraction uncoupling in muscle fatigue
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب تکاملی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
High-frequency tetanic stimulation is associated with an increase in extracellular and T-tubular K+ and changes of Na+ and Clâ concentrations, membrane depolarization as well as inactivation of voltage-gated Na+ channels. These alterations are expected to lead to fiber inexcitability, which is largely prevented by mechanisms intrinsic or extrinsic to muscle fibers. They act by adapting electrical membrane properties or by accelerating the reconstitution of ionic homeostasis. The high Clâ conductance of muscle fibers supports the K+ conductance in fast and complete repolarization and creates a mechanism for the fast reuptake of K+, thereby reducing the T-tubular K+ accumulation. Excitability is increased by a Ca2+ and proteinkinase C dependent inhibition of the Clâ conductance which is efficient especially in the T-tubular system. Several mediators activate the Na+/K+-ATPase and thus enhance the restoration of ionic homeostasis. Examples are purines (ATP, ADP), calcitonin-gene related peptide and adrenaline. It is also necessary to adapt the strength of the sarcoplasmic Ca2+ concentration to the requirements of tetanic contractions. An overwhelming Ca2+ signal leads to enzymatically driven excitation-contraction uncoupling. This process is most likely driven by the Ca2+ dependent protease μ-calpain and might lead to the long-lasting fatigue observed after excessive physical activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuromuscular Disorders - Volume 22, Supplement 3, 1 December 2012, Pages S162-S167
Journal: Neuromuscular Disorders - Volume 22, Supplement 3, 1 December 2012, Pages S162-S167
نویسندگان
Michael Fauler, Karin Jurkat-Rott, Frank Lehmann-Horn,