کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6042321 1189782 2014 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Clinical ObservationsFever of Unknown Origin as the Initial Manifestation of Valproate-Induced Fanconi Syndrome
ترجمه فارسی عنوان
مشاهدات بالینی هر منبع ناشناخته به عنوان اولین تظاهرات سندرم فانکونی ناشی از یک والپروات
کلمات کلیدی
سندرم فانکونی، والپروات تب از منشا ناشناخته، اثرات جانبی، سندرم فانکونی ناشی از والپروات،
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب تکاملی
چکیده انگلیسی

BackgroundValproate-induced Fanconi syndrome is a rare adverse effect of valproate. Severely disabled patients who require tube feeding are reported to be susceptible to valproate-induced Fanconi syndrome. Although most patients with valproate-induced Fanconi syndrome are asymptomatic and detected incidentally with findings such as hypophosphatemia, hypouricemia, increased urinary β2-microglobulin, and generalized hyperaminoaciduria, clinical symptoms such as bone fracture, fever, tachypnea, and edema have been reported.Patient descriptionThis 15-year-old, severely disabled, tube-fed, male patient with cytochrome oxidase deficiency had taken valproate for 3 years when he developed fever for 3 weeks. Hypophosphatemia, hypouricemia, hypokalemia, increased urinary β2-microglobulin, and generalized hyperaminoaciduria, as well as hypocarnitinemia, were found, indicating that he had Fanconi syndrome. Valproate was the most likely cause of Fanconi syndrome in this patient. After discontinuation of valproate, the fever resolved immediately, and the laboratory findings normalized.ConclusionValproate-induced Fanconi syndrome should be considered when individuals taking valproate develop fever of unknown origin.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pediatric Neurology - Volume 51, Issue 6, December 2014, Pages 846-849
نویسندگان
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