کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6056893 | 1199147 | 2014 | 9 صفحه PDF | دانلود رایگان |
ObjectiveThe aim of this study was to evaluate the healing effect of topically applied platelet-rich fibrin (PRF) on experimental oral mucositis induced by chemotherapy in hamsters.Study DesignOral mucositis was induced in 93 Syrian golden hamsters by an intraperitoneal injection of 5-fluorouracil, which was followed by light scratching of the cheek pouch. The hamsters were randomly divided into a PRF group, a fibrin group, and an untreated control group. The recovery stage of oral mucositis was evaluated through daily weighing, measurements of the ulcer area, histopathologic analysis, and a myeloperoxidase activity assay.ResultsThe PRF group exhibited significant improvements in the size and histologic features of the ulcer and in the myeloperoxidase activity compared with the control group (P < .05).ConclusionsThe current findings suggest the consideration for future clinical trials in humans.
Journal: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Volume 117, Issue 4, April 2014, Pages 445-453