Oral and maxillofacial surgeryOnline only articleIntralesional infiltration of corticosteroids in the treatment of localized Langerhans cell histiocytosis of the mandible: report of two cases

ObjectiveThis study was undertaken to describe 2 cases of localized Langerhans cell histiocytosis (LLCH) of the mandible that healed quickly following intralesional infiltration of corticosteroids.Study DesignTwo patients with LLCH of the mandible were treated in a 1-stage procedure with intralesional injection of methylprednisolone. Symptoms of pain were quickly relieved and the swelling receded. Periodic orthopantomogram and computerized tomography after corticosteroid injection revealed continuous regression of mandibular osteolysis and a favorable osseous consolidation in the lesions.ConclusionsThe results of this report suggest that intralesional injection of corticosteroids should be the initial choice of treatment of LLCH of the mandible, especially in children to preserve tooth germs.