کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6058166 1199161 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Oral medicineOnline only articleRare diagnosis of IgG4-related systemic disease by lip biopsy in an international Sjögren syndrome registry
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
پیش نمایش صفحه اول مقاله
Oral medicineOnline only articleRare diagnosis of IgG4-related systemic disease by lip biopsy in an international Sjögren syndrome registry
چکیده انگلیسی

IgG4-related disease has been recently defined as a distinct clinic-pathologic entity, characterized by dense IgG-4 plasmacytic infiltration of diverse organs, fibrosis, and tumefactive lesions. Salivary and lacrimal glands are a target of this disease and, when affected, may clinically resemble Küttner tumor, Mikulicz disease, or orbital inflammatory pseudotumor. In some patients, the disease is systemic, with metachronous involvement of multiple organs, including the pancreas, aorta, kidneys, and biliary tract. We report a 66-year-old man who presented with salivary gland enlargement and severe salivary hypofunction and was diagnosed with IgG4-related disease on the basis of a labial salivary gland biopsy. Additional features of his illness included a marked peripheral eosinophilia, obstructive pulmonary disease, and lymphoplasmacytic aortitis. He was evaluated in the context of a research registry for Sjögren syndrome and was the only 1 of 2594 registrants with minor salivary gland histopathologic findings supportive of this diagnosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Volume 115, Issue 3, March 2013, Pages e34-e39
نویسندگان
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