کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6059039 1199173 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Oral and maxillofacial pathologyComparison of Ki-67, cyclin E, and p63 in benign and malignant human pleomorphic adenoma
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
پیش نمایش صفحه اول مقاله
Oral and maxillofacial pathologyComparison of Ki-67, cyclin E, and p63 in benign and malignant human pleomorphic adenoma
چکیده انگلیسی

ObjectiveA set of cell proliferation-related molecular markers was used to detect the differences in proliferative activity between benign pleomorphic adenoma (PA) and carcinoma ex pleomorphic adenoma (CXPA).Study DesignSeventy samples comprising 53 PAs, 10 noninvasive and 7 widely invasive (WI) CXPAs were selected. Immunohistochemical staining was used to detect Ki-67, cyclin E, and p63 expression.ResultsThe average Ki-67 labeling index of WI CXPAs was higher than that of PAs and the malignant component of noninvasive CXPAs (M-noninvasive CXPA; P < .01). An increased cyclin E-positive staning was observed in M-noninvasive CXPAs and WI CXPAs compared with PAs (P = .006). The p63 expression levels were notably decreased in M-noninvasive CXPAs and WI CXPAs compared with PAs (P = .007).ConclusionsThe data support that increased or decreased expression of Ki-67, cyclin E, and p63 may indicate the proliferative differences between PA and CXPA.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Volume 113, Issue 5, May 2012, Pages 667-672
نویسندگان
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