کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6059239 1199177 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Oral medicineAntifungal activity of coronarin D against Candida albicans
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
پیش نمایش صفحه اول مقاله
Oral medicineAntifungal activity of coronarin D against Candida albicans
چکیده انگلیسی

ObjectiveThe objective of this study was to investigate the antifungal activity of coronarin D on Candida albicans and its activity was compared with clotrimazole and nystatin.MethodsCoronarin D was extracted by liquid chromatography and used in antifungal testing. The inhibitory effect of coronarin D on C. albicans was determined by cultures and an applied broth dilution test. The rate of fungicidal activity was evaluated by time-kill curves. Morphologic alterations of fungal cells were investigated using scanning electron microscopy.ResultsCoronarin D was effective against C. albicans; the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) were 2 and 4 mg/mL, respectively. The C. albicans killing activity of coronarin D was higher than clotrimazole and nystatin at 2×MFC and 4×MFC, respectively. Morphologic alterations of fungal cells consistent with cell membrane damage were observed in the coronarin D-treated cells.ConclusionsCoronarin D showed promising antifungal activity against C. albicans in vitro.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Volume 114, Issue 1, July 2012, Pages 61-66
نویسندگان
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