کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
606695 1454543 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
How hydrophobically modified chitosans are stabilized by biocompatible lipid aggregates
ترجمه فارسی عنوان
چگونه کیتوزان های اصلاح شده از طریق هیدروببوسی با ترکیبات لیپیدی بیولوژیک تثبیت می شوند
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی شیمی کلوئیدی و سطحی
چکیده انگلیسی

Nanostructured hydrogels composed by biocompatible molecules are formulated and characterized. They are based on a polymer network formed by hydrophobically modified chitosans (HMCHIT or CnCHIT) in which vesicles of monoolein (MO) and oleic acid or sodium oleate (NaO), depending on pH, are embedded. The best conditions for gel formation, in terms of pH, length of the hydrophobic moieties of chitosan, and weight proportion among the three components were estimated by visual inspection of a large number of samples. Among all possible combinations, the system C12CHIT–MO–NaO in the weight proportion (1:1:1) is optimal for the formation of a well-structured gel-like system, which is also confirmed by rheological experiments. Electron paramagnetic resonance (EPR) measurements unambiguously show the presence of lipid bilayers in this mixture, indicating that MO–NaO vesicles are stabilized by C12CHIT even at acid pH.A wide small angle neutron scattering investigation performed on several ternary systems of general formula CnCHIT–MO–NaO shows that the length of the hydrophobic tail Cn is a crucial parameter in stabilizing the polymer network in which lipid vesicles are embedded. Structural parameters for the vesicles are determined by using a multilamellar model that admits the possibility of displacement of the center of each shell. The number of shells tends to be reduced by increasing the polymer content. The thickness and the distance between consecutive lamellae are not influenced by either the polymer or MO–NaO concentration.The hydrogel presented in this work, being fully biocompatible and nanostructured, is well-suited for possible application in drug delivery.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Colloid and Interface Science - Volume 452, 15 August 2015, Pages 160–168
نویسندگان
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