کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
607828 | 1454605 | 2013 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Self-association of zwitterionic polymer–lipid conjugates in water as examined by scattering measurements Self-association of zwitterionic polymer–lipid conjugates in water as examined by scattering measurements](/preview/png/607828.png)
As a model of lipopeptide, a zwitterionic polymer–lipid conjugate was prepared from carboxymethylbetaine monomer (CMB) using a lipophilic initiator having a cholesteryl or dihexadecylglyceryl end group for atom transfer radical polymerization (ATRP). The polymer–lipid conjugates (Lipid-PCMB) obtained could be dispersed in water, and self-association of the compounds could be characterized by both light scattering (dynamic light scattering, DLS; electrophoretic light scattering, ELS) and small-angle X-ray scattering (SAXS). DLS and ELS measurements showed no secondary aggregation of the self-associated Lipid-PCMB molecules in salt solutions, though their surfaces were almost charge-balanced. The hydrophilic PCMB layer of Lipid-PCMB aggregates gave rise to dispersions under ionic conditions. Furthermore, structural analyses by DLS, ELS and SAXS measurements suggested that Lipid-PCMB aggregates consisted of a hydrophobic lipid core and a hydrophilic PCMB layer, that is, a core–shell structure. To the best our knowledge, this is the first study in which SAXS analyses were performed for zwitterionic polymer–lipid conjugates.
Figure optionsDownload high-quality image (56 K)Download as PowerPoint slideHighlights
► Zwitterionic polymers having cholesteryl or dihexadecylglyceryl end groups.
► Characterization of the compounds in water by scattering techniques.
► No secondary aggregation of the self-associated conjugates in salt solutions.
► Structural analyses suggested a core–shell structure of the compounds in water.
Journal: Journal of Colloid and Interface Science - Volume 390, Issue 1, 15 January 2013, Pages 47–53