کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
608382 880587 2012 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis, characterization and examination of Gd[DO3A-hexylamine]-functionalized silica nanoparticles as contrast agent for MRI-applications
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی شیمی کلوئیدی و سطحی
پیش نمایش صفحه اول مقاله
Synthesis, characterization and examination of Gd[DO3A-hexylamine]-functionalized silica nanoparticles as contrast agent for MRI-applications
چکیده انگلیسی

Spherical, nonporous and monodisperse silica nanoparticles (NPs) with a diameter of about 100 nm were synthesized and covalently functionalized with lanthanoid(III) (Ln = Gd or Y) chelate complexes, which serve as contrast agents (CAs) for magnetic resonance imaging (MRI). The materials were fully characterized after each synthetic step by different analytical methods, such as dynamic light scattering, scanning electron microscopy, DRIFT and NMR spectroscopy, thermogravimetry and elemental analysis, as well as zetapotential measurements. High surface concentrations of Gd(III) complexes (up to 50 μmol g−1) were determined by ICP-AES and T1-measurements, respectively. MRI experiments show the typical concentration-dependent increase of the longitudinal relaxation rate. T1-weighted images of samples with more than 25 μg NPs per 100 μL agar display a clear contrast enhancement in the agar layer. The transverse relaxivities r2 of the materials are significantly higher than r2 of the corresponding free Gd(III) complexes in water and medium, whereas the longitudinal relaxivities r1 are slightly increased. Due to the high loading of Gd(III) complexes, the relaxivities per particle are remarkably high (up to 2.78 × 105 mM−1 s−1 for r1). Thus, new hybrid materials, based on nonporous silica NPs with high local relaxivity values were synthesized, which can serve as very effective CAs for MRI.

Figure optionsDownload high-quality image (112 K)Download as PowerPoint slideHighlights
► Nanoparticulate contrast agents for magnetic resonance imaging.
► Silica nanoparticles were covalently functionalized with Gd(III) chelate complexes.
► Detailed quantification of the surface functionalization is reported.
► High local relaxivities per nanoparticle were obtained.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Colloid and Interface Science - Volume 366, Issue 1, 15 January 2012, Pages 70–79
نویسندگان
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