Interaction of cationic liposomes with cell membrane models

The interaction of phosphatidylcholine liposomes used as cell models, with cationic liposomes formulated with 1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine and amphiphiles based on a pyrrolidinium headgroup was investigated by differential scanning calorimetry and fluorescence resonance energy transfer experiments. The results obtained showed that subtle variations in the formulation can influence lipid interactions and were correlated to a previous biological evaluation.

The interaction of cell models with cationic liposome was studied by DSC and flourescence measurements.Figure optionsDownload high-quality image (173 K)Download as PowerPoint slideResearch highlights
► Phosphatidylcholine vesicles used as cell models were treated with cationic vesicles.
► The interaction was evaluated by DSC and fluorescence on MLVs and LUVs, respectively.
► Subtle changes in vesicles composition influenced their interaction with cell models.