کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6087995 1207683 2016 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Liver, Pancreas and Biliary TractAssessment of liver fibrosis in primary biliary cholangitis: Comparison between indirect serum markers and fibrosis morphometry
ترجمه فارسی عنوان
کبد، پانکراس و مجاری صفراوی بررسی فیبروز کبدی در کلانژیت صفراوی اولیه: مقایسه بین نشانگرهای غیرمستقیم سرم و فوربروس مورفومتری
کلمات کلیدی
فیبریزه، نشانگرهای غیر مستقیم سرم، مراحل لودویگ، مورفومتری، سیروز اولیه صفراوی،
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
چکیده انگلیسی

BackgroundThe accuracy of non-invasive methods for the quantification of liver fibrosis in primary biliary cholangitis (PBC) is still debated.AimsTo determine the histo-morphometric measurement of fibrotic tissue and to explore the possible association between indirect markers (APRI, FORNS, FIB-4, and Lok) and morphometry.MethodsRetrospective analysis of medical data from patients with PBC, on whom needle liver biopsy was performed as part of the diagnostic assessment. One section of each biopsy stained with Sirius red was used for calculating the percentage of collagen. Quantitative measure of fibrotic tissue (fibrosis morphometry) was calculated as a percentage of collagen content by digital image analysis. Morphometry results were divided into four groups reflecting Ludwig's staging and compared with values for indirect serum markers.Results50 PBC patients were enrolled (86% females, mean age 57 ± 12.30 years), 19 were Ludwig's stage I (38%), 14 stage II (28%), 12 stage III (24%), and five stage IV (10%). Morphometry results were significantly different among Ludwig stages (p < 0.05). No significant differences were found for indirect serum markers. A significant correlation was found between morphometry results and indirect serum markers tested (p < 0.05).ConclusionIn our cohort, the histo-morphometric values of fibrotic tissue increased progressively with Ludwig's stages of PBC, while non-invasive markers did not.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Digestive and Liver Disease - Volume 48, Issue 3, March 2016, Pages 298-301
نویسندگان
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