کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6088055 | 1207685 | 2016 | 6 صفحه PDF | دانلود رایگان |
BackgroundWe aimed to prospectively assess whether endoscopic recurrence severity at 1 year in Crohn's disease is predictive of clinical recurrence within 5 years.MethodsClinical recurrence (Crohn's Disease Activity Index > 150) was assessed yearly for 5 years in Crohn's disease patients undergoing ileo-colonic resection. At 1 year, recurrence was assessed by colonoscopy (Rutgeerts' score â¥i1 or â¥2i) and small intestine contrast ultrasonography.Results40 patients were included (23 males, median age 39 [16-69] years). Clinical recurrence occurred within 5 years in 16 (40%) patients (years 1, 2, 3, 4, 5: 2 [5%]; 10 [25%]; 4 [10%]; 2 [5%]; 4 [10%], respectively). At 1 year, endoscopic recurrence (score â¥Â i1) occurred in 39 (97.5%) patients (score â¥Â i2: 33 [82.5%]). Ultrasound detected lesions compatible with recurrence in 39/40 (97.5%) patients. Endoscopic score at 1 year was correlated with clinical score at 2 years (p = 0.007; r = 0.41). Endoscopic score at 1 year was higher in patients with (n = 10) vs without (n = 30) clinical recurrence at 2 years (3 [2-4] vs 2 [0-4]; p = 0.003). Higher endoscopic score (>i2) at 1 year was a risk factor for clinical recurrence within 5 years (OR = 0.18; 95% CI 0.04-0.71; p = 0.008).ConclusionsIn Crohn's disease, severity of endoscopic recurrence at 1 year remains a predictive marker of clinical recurrence within 5 years. Small intestine contrast ultrasonography is useful for assessing 1-year recurrence.
Journal: Digestive and Liver Disease - Volume 48, Issue 5, May 2016, Pages 489-494