کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6088264 1207697 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Alimentary TractGeranylgeranylacetone protects against small-intestinal injuries induced by diclofenac in patients with rheumatic diseases: A prospective randomized study
ترجمه فارسی عنوان
داروهای گیاهی گرانیل آستون از آسیب های کوچک روده ای ناشی از دی کولفناک در بیماران مبتلا به بیماری های روماتیسمی محافظت می کند: یک مطالعه ی کارآزمایی بالینی تصادفی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
چکیده انگلیسی

BackgroundWe aimed to explore the effect of geranylgeranylacetone on small-intestinal mucosal injuries induced by diclofenac sodium in patients with rheumatic diseases.MethodsThe patients were randomly divided into two groups in our prospective study. The patients in the geranylgeranylacetone group received diclofenac sodium plus geranylgeranylacetone, and those in the control group received only diclofenac sodium for 12 weeks. We examined small-intestinal mucosal injuries using capsule endoscopy before and after treatment.ResultsThere were no significant differences between geranylgeranylacetone (n = 21, male: 42.9%; age: 31.0 ± 9.0 year) and control (n = 19, male: 68.4%; age: 31.0 ± 11.0 year) groups in terms of the numbers of patients with petechiae/red spots, denuded areas and mucosal breaks at baseline capsule endoscopy. After treatment, the numbers of patients with denuded areas (χ2 = 0.000, P = 1.000) and mucosal breaks (χ2 = 1.750, P = 0.186) did not increase in the geranylgeranylacetone group. However, the numbers of patients with petechiae/red spots (χ2 = 5.216, P = 0.022), denuded areas (χ2 = 8.686, P = 0.003) and mucosal breaks (χ2 = 7.795, P = 0.005) increased after treatment in the control groups. Geranylgeranylacetone improved both the Lewis score (Z = −2.459, P = 0.017) and degree (χ2 = 5.414, P = 0.020) on capsule endoscopy 12 weeks later.ConclusionsIn patients with rheumatic diseases, geranylgeranylacetone is effective for protecting against small-intestinal mucosal injuries induced by diclofenac sodium.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Digestive and Liver Disease - Volume 47, Issue 4, April 2015, Pages 280-284
نویسندگان
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