کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6088405 | 1207703 | 2015 | 7 صفحه PDF | دانلود رایگان |
BackgroundNon-alcoholic fatty liver disease is a major health problem worldwide. Resveratrol is a natural polyphenol found in edible plants that has a variety of biochemical and physiological effects.AimsTo evaluate the effect of resveratrol on insulin resistance, glucose and lipid metabolism in non-alcoholic fatty liver disease.MethodsDouble-blind, randomized, placebo-controlled trial: 60 subjects with non-alcoholic fatty liver disease were given 2 placebo capsules (placebo group) or 2 150 mg resveratrol capsules (resveratrol group) twice daily for three months. Liver ultrasound imaging, anthropometric profile, serum liver enzymes, insulin, glucose, C-peptide, lipid profile, and inflammation-related cytokines were compared pre and post-treatment.ResultsCompared with the placebo group, resveratrol significantly decreased aspartate aminotransferase, glucose and low-density lipoprotein cholesterol [â6.00 (â9.00, â3.00) IU/L, â0.64 ± 0.31 mmol/L, and â0.41 ± 0.35 mmol/L, respectively, P â¤Â 0.001] alanine aminotransferase, total cholesterol [â7.00 (â11.0, â2.50) IU/L and â0.67 ± 0.50 mmol/L, respectively, P = 0.002], and homeostasis model assessment insulin resistance index (â0.60 ± 1.15, P = 0.016). In the resveratrol group significant reductions of the levels of tumour necrosis factor-alpha, cytokeratin 18 fragment, and fibroblast growth factor 21 [â0.53 ± 1.30 pg/mL, â26.9 (â70.3, 5.12) IU/L and â23.3 (â43.0, 0.31) pg/mL, respectively, P < 0.05] and elevation of adiponectin level [1.22 (â0.37, 1.60) ng/mL, P = 0.025] were observed.ConclusionResveratrol supplementation may benefit patients with non-alcoholic fatty liver disease.
Journal: Digestive and Liver Disease - Volume 47, Issue 3, March 2015, Pages 226-232