کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6088432 1207706 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Liver, Pancreas and Biliary TractDeterminants of alanine aminotransferase levels in a large population from Southern Italy: Relationship between alanine aminotransferase and age
ترجمه فارسی عنوان
کبد، پانکراس و ترشحات صفراوی تعیین کننده های سطح آلانین آمینوترانسفراز در جمعیت بزرگی از جنوب ایتالیا: رابطه بین آلانین آمینوترانسفراز و سن
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
چکیده انگلیسی

BackgroundDeterminants of alanine aminotransferase levels have never been investigated in real-life settings. The relationship between alanine aminotransferase and age remains controversial. We evaluated epidemiological, anthropometric, and metabolic factors associated with alanine aminotransferase, focusing on the relationship between alanine aminotransferase and age.MethodsA 5-year retrospective analysis was performed on data recorded by 120 general practitioners from Naples (Italy), caring for 170,000 subjects. Exclusion criteria were age <18 years, diagnosis of chronic liver disease, positive markers for viral hepatitis, alcohol abuse, and alanine aminotransferase >100 UI/L.Results44,232 subjects were enrolled (42.7% males, mean age 56 ± 18 years). Alanine aminotransferase showed independent direct associations with body mass index, glycaemia, cholesterol, and triglycerides (p < 0.001), and inverse associations with high-density lipoprotein cholesterol (p < 0.001) and creatinine (p < 0.01). The relationship between alanine aminotransferase and age was better expressed by polynomial regression (r = 0.18, p < 0.001), creating an inverted parabola. Mean alanine aminotransferase increased until the third decade in males and the fifth in females, with a subsequent progressive decrease in both genders. The inverse association between alanine aminotransferase and age in older subjects was independent from metabolic factors.ConclusionsThis real-life setting study, supports the concept that dysmetabolism is a strong determinant of liver injury. Based on our data, a reduction of the standard upper limit of normal alanine aminotransferase should be considered for older subjects.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Digestive and Liver Disease - Volume 46, Issue 10, October 2014, Pages 909-915
نویسندگان
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