کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6088525 | 1207710 | 2015 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Alimentary TractTripterygium wilfordii Hook. f. versus azathioprine for prevention of postoperative recurrence in patients with Crohn's disease: A randomized clinical trial Alimentary TractTripterygium wilfordii Hook. f. versus azathioprine for prevention of postoperative recurrence in patients with Crohn's disease: A randomized clinical trial](/preview/png/6088525.png)
BackgroundTripterygium wilfordii Hook. f. (TwHF) has been used for many years to induce the remission of Crohn's disease in China.AimsTo compare TwHF versus azathioprine for the prevention of postoperative recurrence in Crohn's disease.Methods90 Crohn's disease patients who had undergone resection were treated with TwHF 1.5Â mg/kg/day or azathioprine 2.0Â mg/kg/day. The primary endpoint was clinical recurrence, and the secondary endpoint was endoscopic recurrence.Results47 patients completed the trial. Clinical recurrence was observed in 6/45 patients in the TwHF group and 4/45 patients in the azathioprine group at week 26 (PÂ =Â 0.74). At week 52, 8/45 azathioprine patients and 12/45 TwHF patients had clinical recurrence (PÂ =Â 0.45). During the first 26 weeks, 56.8% of the patients in the TwHF group versus 47.7% in the azathioprine group experienced endoscopic recurrence (PÂ =Â 0.52). However, at week 52, 74.4% of patients in the TwHF group and 50% in the azathioprine group had endoscopic recurrence (PÂ =Â 0.03).ConclusionsTwHF was less effective in maintaining endoscopic remission at week 52, even though TwHF was comparable to azathioprine for preventing postoperative clinical recurrence.
Journal: Digestive and Liver Disease - Volume 47, Issue 1, January 2015, Pages 14-19