کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6088886 1208140 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Original ArticlesDoes fibrin glue sealant decrease the rate of anastomotic leak after a pancreaticoduodenectomy? Results of a prospective randomized trial
ترجمه فارسی عنوان
مقالات اصلی آیا فیبرین چسب سیلانت باعث کاهش میزان نشت انستوموتیک پس از پانکراس دیویدونوکتومی می شود؟ نتایج یک آزمایش تصادفی آیندهنگر
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
چکیده انگلیسی

BackgroundThe aim of this study was to evaluate the effect of topical fibrin glue applied externally to all anastomoses after a pancreaticoduodenectomy (PD) on drain lipase levels, anastomotic leaks, complication rates and length of hospital stay.MethodsA standardized non‐pylorus preserving PD was performed with or without fibrin glue applied to each anastomosis.ResultsFifty‐seven patients were randomized: 32 with and 25 without TISSEEL. There were no statistical differences in each group with respect to drain lipase levels (high 40% versus 43%, P = 0.794), complications including gastric or biliary leaks (24% versus 28%, P = 1.00), wound infection (16% versus 9%, P = 0.28) and a Clavien score of 3 or more (16% versus 25%, P = 0.757) or hospital stay (12 versus 17 days, P = 0.777). Most patients with elevated drain lipase levels had an unaltered clinical course not predictive of adverse outcomes. However, the operative finding of a soft pancreas (27 out of 57 patients) was associated with post‐operative complications (P = 0.002). There were no peri‐operative deaths.Conclusions1Fibrin glue application to all anastomoses does not alter drain lipase levels.2Drain lipase levels are not a significant surrogate marker for clinically significant anastomotic leaks or complications.3Fibrin glue application did not reduce the incidence of an anastomotic leak or complications.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: HPB - Volume 15, Issue 8, August 2013, Pages 561-566
نویسندگان
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