کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6092046 | 1209774 | 2016 | 44 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Leukocyte Trafficking to the Small Intestine and Colon
ترجمه فارسی عنوان
لکوسیت قاچاق به روده کوچک و کولون
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کلمات کلیدی
IELTNFVCAM1T-regulatory cellmucosal vascular addressin cell adhesion molecule 1MLNPLNTregICAM1GALTHEVDSSIBDCDCPDCgut-associated lymphoid tissue - باکتری لنفوئیدی مرتبط با رودهInflammatory bowel disease - بیماریهای التهابی رودهIntestine - رودهT-helper cell - سلول T helperDendritic cell - سلول دندریتیکPlasmacytoid dendritic cell - سلول دندریتیک پلاسماییکوئیدconventional dendritic cell - سلول های دندریتی معمولیdextran sodium sulfate - سولفات سدیم سدیمtumor necrosis factor - فاکتور نکروز تومورLeukocyte trafficking - قاچاق لکوسیتIntraepithelial lymphocyte - لنفوسیت داخل اپیتلیالintercellular adhesion molecule-1 - مولکول چسبندگی بین سلولی -1vascular cell adhesion molecule-1 - مولکول چسبندگی سلولی عروقی-1Adhesion molecules - مولکولهای چسبندگیhigh endothelial venule - ونول اندوتلیوم بالاVascular adhesion protein-1 - پروتئین چسبندگی عروقی-1Peyer’s patch - پیک پچPeripheral Lymph Node - گره لنفاوی محیطیmesenteric lymph node - گره لنفاوی مزانتریکChemokine receptors - گیرنده های شیمیایی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
چکیده انگلیسی
Leukocyte trafficking to the small and large intestines is tightly controlled to maintain intestinal immune homeostasis, mediate immune responses, and regulate inflammation. A wide array of chemoattractants, chemoattractant receptors, and adhesion molecules expressed by leukocytes, mucosal endothelium, epithelium, and stromal cells controls leukocyte recruitment and microenvironmental localization in intestine and in the gut-associated lymphoid tissues (GALTs). Naive lymphocytes traffic to the gut-draining mesenteric lymph nodes where they undergo antigen-induced activation and priming; these processes determine their memory/effector phenotypes and imprint them with the capacity to migrate via the lymph and blood to the intestines. Mechanisms of T-cell recruitment to GALT and of T cells and plasmablasts to the small intestine are well described. Recent advances include the discovery of an unexpected role for lectin CD22 as a B-cell homing receptor GALT, and identification of the orphan G-protein-coupled receptor 15 (GPR15) as a T-cell chemoattractant/trafficking receptor for the colon. GPR15 decorates distinct subsets of T cells in mice and humans, a difference in species that could affect translation of the results of mouse colitis models to humans. Clinical studies with antibodies to integrin α4β7 and its vascular ligand mucosal vascular addressin cell adhesion molecule 1 are proving the value of lymphocyte trafficking mechanisms as therapeutic targets for inflammatory bowel diseases. In contrast to lymphocytes, cells of the innate immune system express adhesion and chemoattractant receptors that allow them to migrate directly to effector tissue sites during inflammation. We review the mechanisms for innate and adaptive leukocyte localization to the intestinal tract and GALT, and discuss their relevance to human intestinal homeostasis and inflammation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gastroenterology - Volume 150, Issue 2, February 2016, Pages 340-354
Journal: Gastroenterology - Volume 150, Issue 2, February 2016, Pages 340-354
نویسندگان
Aida Habtezion, Linh P. Nguyen, Husein Hadeiba, Eugene C. Butcher,