Electrostatic effects on deposition of multiple phospholipid bilayers at oxide surfaces

► Oxide-induced vesicle rupture enhanced by passage through the lipid phase transition. ► DPPC adsorption on oxide particles occurs as stacked planar bilayers. ► Bilayer stacking influenced by oxide and lipid charges, ionic strength, and Ca2+. ► Electrostatic and van der Waals forces dominantly control number of stacked bilayers.