Tumor Necrosis Factor Receptor 2 Restricts the Pathogenicity of CD8+ T Cells in Mice With Colitis

TNFR2 protects mice from colitis by inhibiting the expansion of colonic CD8+ T cells. TNFR2 regulates expression of genes that regulate CD8+ T cells and have been associated with susceptibility to IBD. Disruption in TNFR2 signaling might therefore be associated with pathogenesis. Strategies to increase levels or activity of TNFR2 and thereby reduce the activity of CD8+ T cells might be developed to treat IBD patients with CD8+ T cell dysfunction.