Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology

Undifferentiated or crypt-like, and differentiated or villus-like, human enteroids represent distinct points along the crypt-villus axis; they can be used to characterize electrolyte transport processes along the vertical axis of the small intestine. The duodenal enteroid model showed that electrogenic Na+/HCO3- cotransporter 1 might be a target in the intestinal mucosa for treatment of secretory diarrheas.