Copper complexed polymer carriers for IgG adsorption

Cost effective adsorption matrix is recently, a much sought after alternative to the normal and expensive forms of matrices that are being used for the separation and purification of therapeutic molecules like immunoglobulins. A study therefore, has been focussed on developing copper complexed poly (vinyl alcohol) [PVA] and poly (styrene allyl alcohol) [PSA] gel beads for the separation of immunoglobulin G (IgG) from aqueous solutions. The copper-immobilized PVA and PSA gel beads were prepared, characterized and the copper content was estimated using EDX analysis. Further compatibility tests such as erythrocyte aggregation, lyses and cell counting were also investigated. An increase in the IgG adsorption capacities was achieved with the copper immobilized micro particles, when compared with the unmodified particles.

Copper ion complexed poly (vinyl alcohol) and poly (styrene allyl alcohol) polymers generated micro particles that proved to be facile and economical with enhanced IgG adsorption..Figure optionsDownload high-quality image (41 K)Download as PowerPoint slideResearch highlights
► The adsorption of IgG is enhanced by the metal complexation behaviour of polymer micro particles.
► The metal complexes of micro particles were prepared by simple mixing of metal salt solution and polymer solutions of suitable concentration.
► A substantial adsorption was observed compared to the uncomplexed micro particle and the method adopted was facile and economical.