Original articleClinical endoscopyNarrow-band imaging versus white light for the detection of proximal colon serrated lesions: a randomized, controlled trial

BackgroundThe value of narrow-band imaging (NBI) for detecting serrated lesions is unknown.ObjectiveTo assess NBI for the detection of proximal colon serrated lesions.DesignRandomized, controlled trial.SettingTwo academic hospital outpatient units.PatientsEight hundred outpatients 50 years of age and older with intact colons undergoing routine screening, surveillance, or diagnostic examinations.InterventionsRandomization to colon inspection in NBI versus white-light colonoscopy.Main Outcome MeasurementsThe number of serrated lesions (sessile serrated polyps plus hyperplastic polyps) proximal to the sigmoid colon.ResultsThe mean inspection times for the whole colon and proximal colon were the same for the NBI and white-light groups. There were 204 proximal colon lesions in the NBI group and 158 in the white light group (P = .085). Detection of conventional adenomas was comparable in the 2 groups.LimitationsLack of blinding, endoscopic estimation of polyp location.ConclusionNBI may increase the detection of proximal colon serrated lesions, but the result in this trial did not reach significance. Additional study of this issue is warranted. (Clinical trial registration number: NCT01572428.)