Original articleClinical endoscopyDouble-balloon enteroscopy in Crohn's disease: findings and impact on management in a multicenter retrospective study

BackgroundDouble-balloon enteroscopy (DBE) is effective in visualizing the small bowel to perform biopsy sampling and interventions. Few studies have evaluated the utility of DBE in patients with known or suspected Crohn's disease (CD).ObjectiveTo evaluate the use of DBE in the diagnosis and impact on patient management in known and suspected CD and to compare capsule endoscopy (CE) with DBE findings.DesignRetrospective study from August 2004 to August 2009 of DBE procedures.SettingFive academic, tertiary U.S. centers.PatientsPatients with known or suspected CD.Main Outcome MeasuresDiagnostic yield, impact on patient management, and comparison of DBE to CE findings in patients with known and suspected CD.ResultsWe analyzed 98 DBE procedures performed in 81 patients (38 with known CD and 43 with suspected CD). For patients with CD, common indications were abdominal pain and bleeding/anemia. The diagnostic yield was 87% (33/38 patients). The impact on subsequent management decisions was 82% (31/38). Common indications for DBE in patients with suspected CD were abnormal CE or other imaging. The diagnostic yield was 79% (34/43 patients). The impact on subsequent management decisions was 77% (33/43). In 17% of patients (14/81), DBE failed to reach the target lesion. There was 1 perforation, 3 strictures dilated, and 1 of 2 retained capsules recovered. When CE was followed by DBE, 46% of lesions were confirmed on DBE.LimitationsRetrospective analysis, imperfect criterion standard.ConclusionsDBE is an effective technique for assessment of the small bowel in known and suspected CD and affects management. Failure to reach target areas with DBE is not uncommon, and perforations can occur. There is poor correlation between CE and DBE.