کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6098625 | 1210377 | 2010 | 9 صفحه PDF | دانلود رایگان |

BackgroundLow-volume bowel preparations for colonoscopy improve tolerability.ObjectiveWe compared the efficacy, tolerability, and safety of a new low-volume sulfate solution with a standard 4-L polyethylene glycol electrolyte lavage solution as bowel preparation for colonoscopy.DesignMulticenter, single-blind, randomized, noninferiority study.SettingFive academic and community endoscopy centers in the United States.PatientsOne hundred thirty-six outpatients undergoing colonoscopy.InterventionsPatients were randomized to receive 4 L sulfate-free electrolyte lavage solution (SF-ELS) given the night before colonoscopy versus 12 oz oral sulfate solution (OSS) given in equally divided doses the evening before and the morning of colonoscopy.Main Outcome MeasurementsSuccessful (ie, good or excellent) bowel preparation.ResultsSuccessful bowel preparation was more frequent with OSS than with SF-ELS (98.4% vs 89.6%; P = .04). Excellent preparation also was achieved more frequently with OSS (71.4% vs 34.3%; P < .001). Patients receiving OSS had less residual stool in the cecum and ascending colon and less residual fluid in the cecum and ascending, transverse, and descending colon compared with SF-ELS. The percentage of patients with GI side effects and adverse events was not significantly different between the 2 groups.LimitationsThe OSS was administered in split doses, whereas the SF-ELS was administered the evening before (which is its FDA-approved regimen).ConclusionsOral sulfate solution is promising as a safe low-volume preparation for colonoscopy. (Clinical trial registration number: NCT00856843.)
Journal: Gastrointestinal Endoscopy - Volume 72, Issue 2, August 2010, Pages 328-336