کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6099792 | 1211053 | 2012 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Probable diffuse retinopathy caused by adalimumab in a patient with Crohn's disease
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Probable diffuse retinopathy caused by adalimumab in a patient with Crohn's disease Probable diffuse retinopathy caused by adalimumab in a patient with Crohn's disease](/preview/png/6099792.png)
چکیده انگلیسی
Adalimumab is a tumor necrosis factor-α (TNF-α) antagonist used to treat several immunologic diseases. It is believed that unexpected adverse events related to anti-TNF drugs will occur as administration of this drug becomes more widespread. We report the case of a 37-year-old woman who complained of nonspecific abnormalities of vision in both eyes one month after beginning treatment with adalimumab for Crohn's disease. The results of the initial ophthalmologic examination were normal. The visual fields showed diffuse and severe depression in both eyes. Other diseases that could have caused the visual field defects were ruled out. The results of electrophysiological tests were compatible with diffuse bilateral retinopathy. Treatment with adalimumab was discontinued. Six months later, visual field loss persists, although it has improved slightly. To our knowledge, this is the first report of diffuse retinopathy probable caused by systemic administration of adalimumab. This form of retinal toxicity should be considered in patients with disorders of vision treated with this drug.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Crohn's and Colitis - Volume 6, Issue 9, October 2012, Pages 950-953
Journal: Journal of Crohn's and Colitis - Volume 6, Issue 9, October 2012, Pages 950-953
نویسندگان
Paula Marticorena-Álvarez, MarÃa Chaparro, Andrés Pérez-Casas, Aurora Muriel-Herrero, Javier P. Gisbert,