Subgroup analysis of the placebo-controlled CHARM trial: Increased remission rates through 3Â years for adalimumab-treated patients with early Crohn's disease

Adalimumab was superior to placebo for maintaining clinical remission in patients with moderately to severely active CD after 1 year of treatment regardless of disease duration. Clinical remission rates through 3 years of treatment were highest in the shortest disease duration subgroup in adalimumab-treated patients, with a trend to fewer side effects.