Increased levels of circulating Th17 cells in quiescent versus active Crohn's disease

Our data support the involvement of Th17 cells and IL-21- and IL-22-producing CD45RO+CD4 + T cells in CD. Because patients had higher levels in quiescent disease compared with active CD, we question whether Th17 cells are promoters of inflammation. Instead, Th17 cells may counterbalance inflammation and maintain gut homeostasis.