کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6100876 1211088 2008 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
REVIEW ARTICLEIntestinal fibrosis in inflammatory bowel disease - Current knowledge and future perspectives
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
پیش نمایش صفحه اول مقاله
REVIEW ARTICLEIntestinal fibrosis in inflammatory bowel disease - Current knowledge and future perspectives
چکیده انگلیسی

Background and aimsIntestinal fibrosis is a common complication of IBD that can become seriously symptomatic and may require surgical intervention if stricture formation ensues. This review discusses existing and developing knowledge of intestinal fibrosis and its implications for therapy.MethodsReview of the literature, personal communications, unpublished observations.ResultsKnown mechanisms of intestinal fibrosis include fibroblast proliferation and migration, activation of stellate cells, and extraintestinal fibroblast recruitment. However, novel mechanisms are being uncovered, including epithelial-to-mesenchymal transition, endothelial-to-mesenchymal transition, pericyte differentiation, and fibrocyte recruitment. Most of the traditional and novel mechanisms underlying intestinal fibrosis are associated to the presence of chronic inflammation, but is also possible that fibrosis develops independently of persistent immune activation in the gut. At the moment, the development of preventive, non-interventional, and more effective management of intestinal fibrosis is hampered by the lack of a greater knowledge of its basic pathophysiology and predisposing factors.ConclusionsIt is reasonable to expect that therapy of IBD-associated fibrosis will radically improve once the underlying mechanisms are better understood, and therapeutic modalities will emerge that prevent or reverse this complication of IBD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Crohn's and Colitis - Volume 2, Issue 4, December 2008, Pages 279-290
نویسندگان
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