Editorial DeskFrom the Editor's desk....: January 2016

Selection of the monthPlasma exchange improves survival of ALF patients and liver derived exosomes can improve hepatic regenerationDespite improvements in our understanding of acute liver failure, mortality of patients without liver transplantation remains unacceptably high. The study of Larsen et al. describes the results of a landmark randomized clinical trial that took over 10-years to perform and shows that treatment with plasma exchange can improve the survival of ALF patients, providing proof of concept for 'detoxification' systems.