کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6103894 1590326 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research ArticleInjury to peribiliary glands and vascular plexus before liver transplantation predicts formation of non-anastomotic biliary strictures
ترجمه فارسی عنوان
مقالات پژوهشی: آسیب به غدد لنفاوی و پیوند عروق قبل از پیوند کبد، پیشگیری از ایجاد استریکورهای صفراوی غیر آناستوموتیک
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
چکیده انگلیسی

Background & AimsThe peribiliary glands of large bile ducts have been identified as a niche of progenitor cells that contribute to regeneration of biliary epithelium after injury. We aimed to determine whether injury to the peribiliary glands of donor livers is a risk factor for development of non-anastomotic biliary strictures (NAS) after liver transplantation.MethodsIn 128 liver transplant procedures, biopsies were taken from the donor bile duct and injury was assessed using an established histological grading system. Histological severity of injury was subsequently compared in liver grafts that later developed biliary structures vs. uncomplicated liver grafts.ResultsLuminal biliary epithelial loss >50% was observed in 91.8% of the grafts before transplantation, yet NAS occurred in only 16.4%. Periluminal peribiliary glands were more severely injured than deep peribiliary glands located near the fibromuscular layer (>50% loss in 56.9% vs. 17.5%, respectively; p <0.001). Injury of deep peribiliary glands was more prevalent and more severe in livers that later developed NAS, compared to grafts without NAS (>50% loss in 50.0% vs. 9.8%, respectively; p = 0.004). In parallel, injury of the peribiliary vascular plexus was more severe in livers that developed NAS, compared to grafts without NAS (>50% vascular changes in 57.1% vs. 20.3%; p = 0.006).ConclusionInjury of peribiliary glands and vascular plexus before transplantation is strongly associated with the occurrence of biliary strictures after transplantation. This suggests that insufficient regeneration due to loss of peribiliary glands or impaired blood supply may explain the development of biliary strictures.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Hepatology - Volume 60, Issue 6, June 2014, Pages 1172-1179
نویسندگان
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