کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6104012 | 1211134 | 2013 | 8 صفحه PDF | دانلود رایگان |
Background & AimsThe development and progression of non-alcoholic fatty liver disease are associated with aging, obesity, and type 2 diabetes. Understanding the precise regulatory networks of this process will contribute to novel therapeutic strategies.MethodsHepatocyte-specific Men1 knockout mice were generated using Cre/loxP technology. Lipid and glucose metabolic phenotypes and mechanisms were investigated in aging and high-fat diet fed mice.ResultsThe expression of menin, encoded by multiple endocrine neoplasia 1 (Men1) gene, is reduced in the liver of aging mice. Hepatocyte-specific deletion of Men1 induces liver steatosis in aging mice. Menin deficiency promotes high-fat diet-induced liver steatosis in mice. Menin recruits SIRT1 to control hepatic CD36 expression and triglyceride accumulation through histone deacetylation.ConclusionsOur work reveals that the adaptor protein menin is critical for the progression of hepatic steatosis during aging and metabolic imbalance.
Journal: Journal of Hepatology - Volume 59, Issue 6, December 2013, Pages 1299-1306