کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6106420 1211161 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research ArticleEffect of HBV polymerase inhibitors on renal function in patients with chronic hepatitis B
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
پیش نمایش صفحه اول مقاله
Research ArticleEffect of HBV polymerase inhibitors on renal function in patients with chronic hepatitis B
چکیده انگلیسی

Background & AimsTherapy of chronic hepatitis B with HBV-polymerase inhibitors, in particular tenofovir or adefovir, may affect renal function. To assess renal function more accurately in the normal range, we used the recently validated, Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula to calculate the estimated glomerular filtration rate (eGFR).MethodsPatient subgroups included: patients with HBV-monoinfection treated with lamivudine (n = 36), adefovir (n = 32), entecavir (n = 32), or tenofovir (n = 37). HBsAg-positive untreated patients (n = 60) served as control. For comparison HIV-monoinfected patients treated with tenofovir (n = 120) or zidovudine (n = 52) based antiretroviral therapy and antiretroviral naive patients (n = 109) were assessed. CKD-EPI equation was used to calculate eGFR. In a more sensitive approach, we modeled the individual change in eGFR over time with linear mixed effects models (LME).ResultsYearly predicted median changes in individual eGFR according to the LME model were: HBV untreated −2.05 ml/min, HBV lamivudine −0.92 ml/min, HBV adefovir −1.02 ml/min, HBV entecavir −1.00 ml/min, and HBV tenofovir −0.92 ml/min (p <0.01 for HBV untreated vs. HBV treated). In HIV-monoinfected patients: HIV untreated −0.62 ml/min, HIV treated with tenofovir −2.64 ml/min, HIV treated with zidovudine −1.0 ml/min (p = 0.017 for tenofovir vs. no treatment, p <0.001 for tenofovir vs. zidovudine).ConclusionsTherapy of HBV infection irrespective of medication seems to result in a milder decrease of renal function. In contrast tenofovir as part of HIV combination therapy seems to impair renal function in this Caucasian population.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Hepatology - Volume 55, Issue 6, December 2011, Pages 1235-1240
نویسندگان
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