کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6107383 1211172 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Myopathy and neuropathy associated with nucleos(t)ide analog therapy for hepatitis B
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
پیش نمایش صفحه اول مقاله
Myopathy and neuropathy associated with nucleos(t)ide analog therapy for hepatitis B
چکیده انگلیسی
The development of clevudine as a treatment for hepatitis B was terminated recently because of case reports of myopathy. In each case, the onset of symptoms occurred between 8 and 13 months after the initiation of treatment. Electromyography and muscle biopsy confirmed the presence of myonecrosis. One report also found evidence of mitochondrial toxicity. The delayed onset and the finding of mitochondrial damage are reminiscent of fialuridine toxicity. Telbivudine has also been reported to be associated with myopathy and neuropathy, particularly when used in combination with pegylated interferon. These findings serve as a sober reminder of the lack of data on long-term safety of nucleos(t)ide analogs for hepatitis B, the importance of balancing benefits versus risks before initiating treatment, and the need for more stringent post-marketing surveillance for drug toxicities.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Hepatology - Volume 51, Issue 4, October 2009, Pages 787-791
نویسندگان
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