کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6107557 1211174 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Clinical Application of Basic ScienceThe molecular basis of the failed immune response in chronic HBV: Therapeutic implications
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
پیش نمایش صفحه اول مقاله
Clinical Application of Basic ScienceThe molecular basis of the failed immune response in chronic HBV: Therapeutic implications
چکیده انگلیسی

There is a pressing need to develop new immunotherapeutic interventions in chronic hepatitis B virus (HBV) infection in order to limit the high costs and risks of toxicity or viral resistance associated with maintenance antiviral treatment. Here we review recent advances in our understanding of the molecular defects underlying the profound T cell depletion characteristic of these patients. We propose that T cells are driven to apoptosis by the combination of a persistent, high antigen load and excessive inhibitory signals encountered in the hepatic microenvironment. The feasibility of boosting sustained antiviral control by targeted reversal of key tolerising mechanisms is discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Hepatology - Volume 52, Issue 4, April 2010, Pages 616-619
نویسندگان
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