کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6108249 | 1211185 | 2008 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Case ReportAnti-HBs positive occult hepatitis B virus carrier blood infectious in two transfusion recipients Case ReportAnti-HBs positive occult hepatitis B virus carrier blood infectious in two transfusion recipients](/preview/png/6108249.png)
Background/AimsOccult hepatitis B infection (OBI) in blood donations is not considered infectious when anti-HBs is present.MethodsFour months after transfusion of eight blood components during coronary arterial bypass surgery, a 59-year-old patient developed acute hepatitis B. A second 71-year-old patient transfused with a red cell concentrate (RCC) from one of these donations had early HBV infection 7Â months post-transfusion. Samples were tested for HBV serological markers and HBV DNA was quantified and sequenced.ResultsOne implicated donation contained anti-HBc, anti-HBs (12 IU/L) and 180Â IU/ml of HBV DNA. Previous and subsequent samples contained 3-10 times lower viral load and slightly variable anti-HBs. Two previous donations did not cause HBV infection. Recipients of the FFP and RCC from the index donation were both HBV infected and carried genotype D strains with sequences identical to the donor strain.ConclusionsDespite anti-HBs, an OBI carrier transmitted HBV to two immunocompetent transfusion recipients.
Journal: Journal of Hepatology - Volume 48, Issue 6, June 2008, Pages 1022-1025