کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6111492 | 1211730 | 2016 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Early effect of Roux-en-Y gastric bypass on insulin sensitivity and signaling
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Following RYGB, we found a prompt improvement of hepatic insulin resistance with normalization of hepatic insulin clearance and a small amelioration of whole-body insulin sensitivity. The supranormal levels of Akt Ser473 observed at fast in the skeletal muscle tissue at baseline were normalized after RYGB, and their changes correlated with those of both hepatic and peripheral insulin resistance. Although other mechanisms of action, such as the effect of weight loss and reduced food intake, cannot be excluded, the reduction of muscle Akt hyperphosphorylation on the serine residue can play a role in the early improvement of insulin sensitivity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Surgery for Obesity and Related Diseases - Volume 12, Issue 1, January 2016, Pages 42-47
Journal: Surgery for Obesity and Related Diseases - Volume 12, Issue 1, January 2016, Pages 42-47
نویسندگان
Anna Ph.D., Lidia M.D., Marco M.D., Amalia Ph.D., Esmeralda M.D., Amerigo M.D., Caterina M.D., Ph.D., Cosimo M.D., Rocco M.D., Geltrude M.D., Ph.D.,