Preferentially linear connection of gold nanoparticles in derivatization with phosphorothioate oligonucleotides

A gold nanosphere in water is considered to attain special stability in derivatization like an artificial atom when the octet rule is satisfied by forming four covalent bonds with two 5′-phosphorothioate-modified oligonucleotide molecules. Owing to this, the hybridization of two mutually complementary gold-bound oligonucleotides makes gold nanospheres preferentially connected linearly by duplexes to produce strands like linear artificial molecules. We have then fixated the linear strands of DNA-linked gold nanospheres by reducing Ag+ ion clusters immobilized around duplexes to show the absorption spectrum of silver-coated artificial-molecular nanorods.

A gold nanosphere is considered to attain special stability in derivatization when the octet rule is satisfied by forming four covalent bonds with two 5′-phosphorothioate-modified oligonucleotide molecules.Figure optionsDownload as PowerPoint slide