Reagentless functionalization of gold nanoparticles via a 3 + 2 Huisgen cycloaddition

A mild method for functionalization of gold nanoparticles is reported. The reactions of azide functionalized nanoparticles with propynoic acid derivatives provide triazole functionalized nanoparticles under very mild reaction conditions. Characterization of the nanoparticle-bound triazoles using 1H and 13C NMR spectroscopy indicates that both the 1,4 and 1,5 triazole regioisomers are formed on the nanoparticle surface.

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